Return to site entrance
About Our Practice
Physician Information
Services,
Treatment & Care
Patient Information
Department
of Research
Forms &
Communications
Nutrition
Links of Interest
FAQs
Contact Us

©2001 Tyler CVC
 
Physician Information | Published Materials | Professional Research  

Professional Research
Robert J. Carney, MD, FACP, FACC

Principal Investigator

Clinical and Investigational Experience in the Use of a New Drug Permit for the Use of Mexiletin (prior to its release)

  • New Drug Permit for the IV Use of Amiodarone for Refractory and Life-threatening Ventricular Arrhythmias
  • New Drug Permit for the Use of an Implantable Infusion Pump for the Intermittent Infusion of IV Positive Inotropic Agents in Patients Who Are Not Candidates for Cardiac Transplantation
  • The Use of CPK Isoforms in the Identification and Clinical Management of Patients Who Present with Chest Pain in Its Very Earliest Phases
  • FiB072 - A Randomized, Double-blind Study Comparing the Patency Rate and Safety of 2 Different Preparations of IV Eminase (BRL 26921) in Patients with Acute Myocardial Infarction
  • APSAC - A Pre-market Safety and Efficiency Trial of Eminase
  • RAAMI (Rapid Administration of Alteplase (rt-PA) in Myocardial Infarction Trial) - Increased Efficacy of 100 mg of rt-PA with Modified Dosing
  • LATE (Late Assessment of Thrombolytic Efficacy) - An Anglo-Scandinavian North American Multi-center Trial of Alteplase (rt-PA) Therapy in Patients who Present with Acute Myocardial Infarction 6 to 24 Hours Following

Onset of Symptoms

  • ISIS 3 (The Third International Study of Infarct Survival)- A Randomized, Double-blind Study Comparing 3 Different Thrombolytic Agents and 2 Different Anticoagulant Regimens with the Final Endpoint of Mortality Reduction
  • SAVE - The Application of Thrombolytic Agents (tPA) in Myocardial Infarctions in Patients After the Initial 6 Hour Proven Therapeutic Window Involving an Assessment of the Efficacy of Thrombolysis in the Post 6 Hour Myocardial Infarction Patient
  • Safety Trial for Doses of t-PA and Streptokinase Given Simultaneously for Acute Myocardial Infarction
  • CARDIZEM CD - The Safety and Efficacy of Cardizem CD for the Treatment of Stable Angina Pectoris
  • CARS (Coumadin Aspirin Re-infarction Study) - A Randomized, Double-blind Study to Compare the Efficacy and Safety of Fixed Low Doses of Coumadin Plus Aspirin to Aspirin Alone in the Prevention of Re-infarction, Cardiovascular Death, and Stroke in Post Myocardial Infarction Patients
  • DOFETILIDE 128 - A Randomized, Double-blind, Parallel, Placebo-controlled Evaluation of Orally Administered Dofetilide in Patients with Symptomatic Paroxysmal Atrial Fibrillation or Flutter
  • DOFETILIDE 128A Extension - A Long-term Extension Double-blind Converting to Open-Label
  • LIMIT AMI - A Phase II, Randomized, Double-blind, Placebo-controlled Multi-center, Angiographic Trial of the Safety and Efficacy of rhuMAb CD18 in Acute Myocardial Infarction

Sub-Investigator

  • LIMIT - A Multi-center, Prospective Trial in the use of Lopressor in Myocardial Infarction, Demonstrating a Significant Reduction in Mortality with Early IV Use
  • UNSA - A Multi-center, Prospective, Randomized, Placebo-controlled Trial of Activase and Heparin in Patients with Unstable Angina
  • TIMI 3 (Thrombolysis in Myocardial Ischemia and unstable angina) - A Study of the Comprehensive Management of Unstable Angina and Non-Q Wave Myocardial Infarction in a Randomized, Double-blind Fashion with tPA or Placebo
  • TIMI 3B - A Study to Determine If Thrombolytic Therapy Can Reduce the Incidence of Unstable Angina That Progresses to Myocardial Infarction
  • 7E3-Epic - A Study of Chimeric 7E3 Fab in Patients Undergoing High Risk Coronary Angioplasty
  • DUCCS 1 (Duke University Clinical Cardiology Study) - A Study to Compare Efficacy of Eminase With and Without Adjunct Heparin Therapy in Acute Myocardial Infarction
  • CK ASSAY Pilot Study - The Evaluation of the Utility of Early Serial CK Levels
  • DUCCS 2 (Duke University Clinical Cardiology Study) - A Randomized Trial of rt-PA (Activase) with Heparin vs APSAC (Eminase) without Heparin in Acute MI
  • CAVEAT II - Coronary Angioplasty vs Excisional Atherectomy Trial
  • INTEGRELIN - A Randomized, Double-blind Comparative Safety and Efficacy Evaluation of Integrelin versus Aspirin in the Management of Unstable Angina
  • HIRULOG - A Comparative Study for the Safety and Efficacy of B68967 with Heparin Inpatients with Unstable Angina Undergoing PTCA
  • IMPACT - A Randomized, Double-blind Trial of Integrelin vs Placebo in the Setting of Coronary Angioplasty
  • PRAISE (Prospective Randomized Amlodipine Survival Evaluation) - A Randomized, Double-blind, Dose-tritation, Parallel group, Placebo-controlled Study to Evaluate the Effect of Amlodipine on Mortality and Morbidity in Patients with Severe Heart Failure
  • FIRST - A Multi-national, Open, Randomized, Parallel Group Comparison of the Effects of Chronic FLOLAN Therapy Plus Conventional Therapy to Conventional Therapy Alone on Survival in Patients with Severe Refractory Congestive Heart Failure
  • GUARDIAN - A Double-blind Trial to Investigate Whether Cariporide Reduces the Combined Incidence of All-cause Mortality and Myocardial Infarction in Patients at Risk of Myocardial Necrosis Due to ACS Related to the Disease Process or to an Interventional Cardiac Procedure
  • SPEED - A Phase II, Randomized, Open-label, Angiographic Trial Evaluating the Benefit of ReoPro Bolus Plus 12 Hour Infusion With and Without Thrombolytic Therapy for Acute Myocardial Infarction
  • PARAGON B - A Randomized, Double-blind, Placebo-controlled Study of Lamifiban (Ro 44-9883) in Patients with Unstable Angina, Non Q-Wave Myocardial Infarction
  • LEXUS with Gas (Losartan Exercise in the United States with Gas Exchange Analysys) - A Multi-center, Double-blind, Randomized, Parallel, Placebo-controlled Study to Investigaate the Effects of Losartan on the Exercise Capacity and Clinical Status of Patients with Symptomatic Heart Failure
  • PRAISE 2 (Prospective Randomized Amlodipine Survial Evaluation 2) - A Randomized, Placebo-controlled Trial to Evaluate the Effect of Amlodipine on Mortality in Patients with Severe Non-Ischemic Cardiomyopathy
  • SPICE (Study of Patients Intolerant of Converting Enzyme Inhibitors) - A Pilot Phase II Trial and Registry of Patients with Class II-IV Heart Failure and Left Ventricular Dysfunction
  • APLAUD - A 12 Week, Double-blind, Parallel-controlled Study to Assess the Safety, Tolerability, Pharmacokinetics and Effect of Platelet Aggregation of a Dose Range of SB 214857 When Added to Aspirin in Patients with Myocardial Infarction, Unstable Angina, Transient Ischemic Attack, or Stroke
  • SADHART (Sertraline Antidepressant Heart Attack Randomized Trial) - A Randomized, Double-blind, Placebo-controlled Trial of Sertraline for Major Depression After Acute Coronary Syndromes: Myocardial Infarction or Unstable Angina
  • Val-HeFT - A Multi-country, Randomized, Double-blind, Placebo-controlled Trial to Assess the Effect of Valsartan on Morbidity and Mortality, Signs and Symptoms, and Quality of Life in patients with Stable Chronic Congestive Heart Failure
  • ELITE II - A Multi-center, Double-blind, Parallel, Captopril-controlled Study to Evaluate the Effects of Losartan on Mortality in Patients with Symptomatic Heart Failure
  • WIZARD - A Randomized, Double-blind, Placebo-controlled Trial of the Effects of Weekly Azithromycin on the Incidence of Coronary Artery Disease in Subjects with Evidence of Exposure to C. Pneumoniae
  • CAPRICORN - A Multi-national, Multi-center, Randomized, Double-blind, Parallel Group Study to Determine the Effects of Carvedilol on Mortality in Patients with Left Ventricular Dysfunction, With or Without Clinical Evidence of Heart Failure, Post Myocardial Infarction
  • HALT MI - A Phase 2 Safety and Efficacy Study off Hu23F2G on Patients with Acute Myocardial Infarction with Direct Angioplasty
  • ASTRA - A Double-blind, Placebo-controlled, Multi-center Pilot Study to Assess the Safety and ex vivo Platelet Aggregation Response of Intravenous AR-C69931MX in Patients Undergoing Percutaneous Transluminal Coronary Angioplasty, With or Without Intracoronary Stent Placement
  • ASTRA (Part 2 Open-label vs Abciximab) - A Multi-center Pilot Study to Assess the Safety and ex vivo Platelet Aggregation Response of Intravenous AR-C69931MX in Patients Undergoing Percutaneous Transluminal Coronary Angioplasty With or Without Intracoronary Stent Placement
  • INTRO AMI - A Pilot Phase II Safety and Efficacy Evaluation of Eptifbatide (Integrelin) in Patients Receiving Low Dose and Standard Dose Thrombolytic Therapy (Alteplase) for Acute Myocardial Innfaarction (AMI)
  • GUSTO IV ACS - A Phase III, Randomized, Double-blind, Placebo-controlled Trial Evaluating the Efficacy and Safety of ReoProâ Given as a Bolus Followed by a 24 or 48 Hour Infusion for the Treatment of Acute Coronary Syndrome Without ST Segment Elevation
  • GUSTO IV AMI - A Phase III, Randomized, Open-label Trial Evaluating the Efficacy and Safety of ReoProâ (Abciximab) in Combination with Reduced Dose Retavaseâ/RapilysinÔ (Recombinant Plasminogen Activator, Retaplase, r-PA) for the Treatment of Acute Myocardial Infarction
  • AMISTAD II - A Randomized, Double-blind, Placebo-controlled, Multi-center Trial to Evaluate the Efficacy and Safety of Adenosine (Pallcorâ, Adenosine Injection) As an Adjunct to Reperfusion Therapy (Thrombolysis or Mechanical Reperfusion) in the Treatment of Acute Anterolateral Myocardial Infarction
  • A to Z - A Multi-center, Randomized, Controlled, Double-blind Trial to Investigate the Clinical Efficacy and Tolerability of Early Treatment with Simvastatin 40 mg Daily for 30 Days Followed by Simvastatin 80 mg Daily Thereafter in Tirofiban-treated Acute Coronary Syndrome Patients Who Have Been Randomized to Receive Enoxaparin or Unfractionated Heparin in Conjunction with Aspirin
  • BRACCO - A Clinical Evaluation to Determine the Optimal Imaging Parameters for Tc-99m Teboroxime in Subjects with Coronary Artery Disease and Subjects with No Evidence of Coronary Artery Disease
  • TARGET - A Randomized, Multi-center, Double-blind, Abciximab-controlled Study to Evaluate the Efficacy of Tirofiban in Patients Undergoing Percutaneous Intervention with Intracoronary Stent Placement
  • CREDO - A Double-blind, Randomized Trial of Clopidigrel 300 mg Loading Dose and Aspirin 325 mg Followed by Clopidigrel 75 mg and Aspirin Daily Compared with Placebo Loading Dose and Aspiring 325 mg Followed by Clopidigrel 75 mg and Aspirin Daily for the Prevention of Vascular Events and All-cause Mortality in Patients Undergoing Percutaneous Coronary Intervention
  • GOLD - A Prospective, Multi-center, Observational Study Evaluating Platelet Function with the Accumetrics Ultegra-Rapid Platelet Function Assay (RPFA) in Patients Undergoing Interventions Using Platelet Glycoprotein IIb/IIIa Inhibitors
  • POSTIT - Boston Scientific Scimed, Inc.-Post Market Research Study on the NIR Stent and Other Commercially Available Coronary Stents
  • BRAVO - Blockade of the GP IIB/IIIA Receptor to Avoid Vascular Occlusion
  • VALIANT (Valsartan in Acute Myocardial Infarction) - A Multi-national, Multi-center, Double-blind, Randomized, Active-controlled, Parallel Group Study Comparing the Efficacy and Safety of Long-term Treatment with Valsartan, Captopril, and Their Combination in High-risk Patients After Myocardial Infarction
  • CHARM (Candesartan Cilexetil in Heart Failure: Assessment of Reduction in Mortality and Morbidity) - Studies of Candesartan in Patients with Heart Failure Who Are ACE Inhibitor Intolerant and Have Depressed Left Ventricular Systolic Function (0003), Who Are Treated With ACE Inhibitors and Have Depressed Left Ventricular Systolic Function (0006), and Patients with Heart Failure and Preserved Left Ventricular Systolic Function (0007)
  • RAFT - A Double-blind, Placebo-controlled, Randomized Clinical Trial of Slow Release Propafenone (Rythmol®SR) in the Prevention of Symptomatic Recurrences of Atrial Fibrillation
  • OVERTURE - Omapatrilat Versus Enalapril Randomized Trial of Utility in Reducing Events