Professional Research
Roderick B. Meese, MD

Principal Investigator

• PRAISE (Prospective Randomized Amlodipine Survival Evaluation) - A Randomized, Double-blind, Dose-titration, Parallel Group, Placebo-controlled Study to Evaluate the Effect of Amlodipine on Mortality and Morbidity in Patients with Severe Heart Failure
• DUCCS 1 (Duke University Clinical Cardiology Study) - A Randomized Trial of Heparin in Conjunction with Anistreplase in Acute Myocardial Infarction
• DUCCS 2 (Duke University Clinical Cardiology Study) - A Randomized Trial of rt-PA (Activase) With Heparin versus APSAC (Eminase) Without Heparin in Acute Myocardial Infarction
• LEXUS with Gas (Losartan Exercise in the United States with Gas Exchange Analysis) - A Multi-center, Double-blind, Randomized, Parallel, Placebo-controlled Study to Investigate the Effects of Losartan on the Exercise Capacity and Clinical Status of Patients with Symptomatic Heart Failure
• PRAISE 2 (Prospective Randomized Amlodipine Survival Evaluation 2) - A Randomized, Placebo-controlled Trial to Evaluate the Effect of Amlodipine on Mortality in Patients with Severe Non-Ischemic Cardiomyopathy
• ELITE II- A Multi-center, Double-blind, Randomized, Parallel, Captopril-controlled Study to Evaluate the Effects of Losartan on Mortality in Patients with Symptomatic Heart Failure
• A to Z - A Multi-center, Randomized, Controlled, Double-blind Trial to Investigate the Clinical Efficacy and Tolerability of Early Treatment with Simvastatin 40 mg Daily for 30 Days Followed by Simvastatin 80 mg Daily Thereafter in Tirofiban-treated Acute Coronary Syndrome Patients Who Have Been Randomized to Receive Enoxaparin or Unfractionated Heparin in Conjunction with Aspirin
• OVERTURE - Omapatrilat Versus Enalapril Randomized Trial of Utility in Reducing Events Sub-Investigator
• EPIC 7E3 - A Study of Chimeric 7E3 Fab in Patients Undergoing High Risk Coronary Angioplasty
• Cardizem CD - The Safety and Efficacy of Cardizem CD for the Treatment of Stable Angina Pectoris
• Integralin versus Aspirin in Unstable Angina - A Randomized, Double-blind Comparative Safety and Efficacy Evaluation (Phase II) of Integrelin versus Aspirin in the Management of Unstable Angina
• HIRULOG - A Comparative Study for the Safety and Efficacy of B68967 with Heparin in Patients with Unstable Angina Undergoing PTCA
• FIRST - A Multi-national, Open, Randomized, Parallel Group Comparison of the Effects of Chronic Flolan Therapy Plus Conventional Therapy to Conventional Therapy Alone on Survival in Patients with Severe Refractory Congestive Hear Failure
• IMPACT I - A Randomized, Double-blind Trial of Integrelin versus Placebo in the Setting of Coronary Angioplasty
• IMPACT II - A Randomized, Double-blind, Efficacy and Safety Evaluation of Two Dosing Regimens of Integrelin versus Placebo for Reducing the Complication of Coronary Angioplasty
• FiB07 - A Randomized, Double-blind Study Comparing the Patency Rate and Safety of Two Different Preparations of IV Eminase (NRL 26921) in Patients with Acute Myocardial Infarction
• RAAMI (Rapid Administration of Alteplase (rt-PA) in Myocardial Infarction) Increased Efficacy of 100 mg of rt-PA with Modified Dosing
• UNSA - A Multi-center, Prospective, Randomized, Placebo-controlled Trial of Activase and Heparin in Patients with Unstable Angina
• ISIS 3 (International Study of Infarct Survival 3) - A Randomized, Double-blind Study Comparing 3 Different Thrombolytic Agents and 2 Different Anticoagulant Regimens with the Final Endpoint of Mortality Reduction
• TIMI 3B - (Thrombolysis in Myocardial Infarction and Unstable Angina) - A Study to Determine If Thrombolytinc Therapy Can Reduce the Incidence of Unstable Angina That Progresses to Myocardial Infarction
• CK ASSAY - A Pilot Study for Evaluation of the Utility of Early Serial CK Levels
• GUSTO (Global Utilization of Streptokinase and t-PA for Occluded coronary Arteries) An International Study - A comparison of the Effect on Survival of Three Different Thrombolytic Regions - The Angiographic Sub-study will determine the relationship of coronary patency and re-occlusion to patient outcome
• GUSTO Pilot Trial - A Safety Trial for Doses of t-PA and Streptokinase Given Simultaneously for Acute Myocardial Infarction
• CARS (Coumadin Aspirin Reinfarction Study) - A Randomized, Double-blind Study to Compare the Efficacy and Safety of Fixed Low Doses of Coumadin Plus Aspirin to Aspirin Alone in the Prevention of Re-infarction, Cardiovascular Death, and Stroke in Post-myocardial Patients
• Dofetilide 128 - A Randomized, Double-blind, Parallel, Placebo-controlled Evaluation of Orally Administered Dofetilide in Patients with Symptomatic Paroxysmal Atrial Fibrillation of Flutter
• Dofetilide 128A Extension - A Long-term Extension Double-blind Converting to Open-label
• SPICE (Study of Patients Intolerant of Converting Enzyme Inhibitors) - A Pilot Phase II Trial and Registry of Patients with Class II-IV Heart Failure and Left Ventricular Dysfunction
• APLAUD - A 12 Week, Double-blind, Parallel-controlled Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effect on Platelet Aggregation of a Dose Range of SB 214857 When Added to Aspirin in Patients with Myocardial Infarction, Unstable Angina, Transient Ischemic Attack, or Stroke
• SADHART (Sertraline Antidepressant Heart Attack Randomized Trial) - A Randomized, Double-blind, Placebo-controlled Trial of Sertraline for Major Depression After Acute Coronary Syndromes: Myocardial Infarction or Unstable Angina
• Val-HeFT - A Multi-country, Randomized, Double-blind, Parallel, Placebo-controlled Trial to Assess the Effect of Valsartan on Morbidity, Mortality, Signs and Symptoms, and Quality of Life in Patients with Stable, Chronic Congestive Heart Failure (NYHA Class II-IV)
• WIZARD - A Randomized, Double-blind, Placebo-controlled Trial of the Effect of Weekly Azithromycin on the Incidence of Coronary Artery Disease in Subjects with Evidence of Exposure to C. Pneumoniae
• CAPRICORN - A Multi-national, Multi-center, Randomized, Double-blind, Parallel Group Study to Determine the Effects of Carvedilol on Mortality in Patients with Left Ventricular Dysfunction, With or Without Clinical Evidence of Heart Failure, Post Myocardial Infarction
• GUARDIAN - A Double-blind Trial to Investigate Whether Cariporide Reduces the Combined Incidence of All-cause Mortality and Myocardial Infarction in Patients At Risk of Myocardial Necrosis Due to ACS Related to the Disease Process or to an Interventional Cardiac Procedure
• PARAGON B - A Randomized, Double-blind, Placebo-controlled Study of Lamifiban (R044-9883) in Patients with Unstable Angina/Non Q-Wave Myocardial Infarction
• SPEED (Strategies for Patency Enhancement in the Emergency Department) - A Phase II, Randomized, Open-label, Angiographic Trial Evaluating the Benefit of ReoPro Bolus Plus 12 Hour Infusion With and Without Thrombolytic Therapy for Acute Myocardial Infarction