Professional Research
C. Fagg Sanford, III, MD, FACC

Principal Investigator

• TIMI-3 B (Thrombolysis in Myocardial Infarction and Unstable Angina) - A Study to Determine If Thrombolytic Therapy Can Reduce the Incidence of Unstable Angina That Progresses to Myocardial Infarction
• UNSA - A Multi-center, Prospective, Randomized, Placebo-controlled Trial of Activase and Heparin in Patients with Unstable Angina
• FLOLAN - A Multi-national, Open, Randomized, Parallel Group Comparison of the Effects of Chronic FLOLAN Therapy Plus Conventional Therapy to Conventional Therapy Alone on Survival in Patients with Severe Refractory Congestive Heart Failure Sub-investigator
• New Drug Permit for the IV Use of Amiodarone for Refractory and Life-threatening Ventricular Arrhythmias
• FiB07 - A Randomized, Double-blind Study Comparing the Patency Rate and with Safety of Two Different Preparations of IV Eminase (NRL 26921) in Patients Acute Myocardial Infarction
• RAAMI (The Rapid Administration of Alteplase (rt-PA) in Myocardial Infarction) Trial - Increased Efficacy of 100 mg of rt-PA with Modified Dosing
• LATE (Late Assessment of Thrombolytic Efficacy of Alteplase (rt-PA) ) - Therapy in Patients Who Present with Acute Myocardial Infarction 6 to 24 Hours Following Onset of Symptoms
• ISIS-3 (The 3rd International Study of Infarct Survival) - A Randomized Double-blind Study Comparing 3 Different Thrombolytic Agents & 2 Different Anticoagulant Regimens with the Final Endpoint of Mortality Reduction
• New Drug Permit for the Use of an Implantable Infusion Pump for the Intermittent Infusion of IV Positive Inotropic Agents in Patients Who Are Not Candidates for Cardiac Transplantation
• The Use of CPK Isoforms in the Identification and Clinical Management of Patients Who Present with Chest Pain with Chest Pain in Its Very Earliest Phases
• IMPACT - A Randomized, Double-blind Trial of Integrelin versus Placebo in the Setting of Coronary Angioplasty
• PRAISE (Prospective Randomized Amlodipine Survival Evaluation) - A Randomized, Double-blind, Dose-titration, Parallel Group, Placebo-controlled Study to Evaluate the Effect of Amlodipine on Mortality and Morbidity in Patients with Severe Heart Failure
• SAVE - The Application of Thrombolytic Agents (tPA) in Myocardial Infarction in Patients After the Initial 6 Hour Proven Therapeutic Window Involving an Assessment of the Efficacy of Thrombolysis in the Post 6 Hour Myocardial Infarction Patient
• DUCCS-2 (Duke University Clinical Cardiology Study) - A Randomized Trial of rt-PA (Activase) with Heparin vs APSAC (Eminase) without Heparin in Acute MI
• CARDIZEM CD - The Safety and Efficacy of Cardizem CD for the Treatment of Stable Angina Pectoris
• INTEGRELIN - A Randomized, Double-blind Comparative Safety and Efficacy Evaluation of Integrelin versus Aspirin in the Management of Unstable Angina
• HIRULOG - A Comparative Study for the Safety and Efficacy of B68967 with Heparin in Patients with Unstable Angina Undergoing PTCA
• CARS (Coumadin Aspirin Reinfarction Study) - A Randomized, Double-blind Study to Compare the Efficacy and Safety of Fixed Low Doses of Coumadin Plus Aspirin to Aspirin Alone in the Prevention of Reinfarction, Cardiovascular Death, and Stroke in Post-myocardial Infarction Patients
• LEXUS with Gas (Losartan Exercise in the United States with Gas Exchange Analysis) - A Multi-center, Double-blind, Randomized, Parallel, Placebo-controlled Study to Investigate the Effects of Losartan on the Exercise Capacity and Clinical Status of Patients with Symptomatic Heart Failure
• GUARDIAN - A Double-blind Trial to Investigate Whether Cariporide Reduces the Combined Incidence of All-cause Mortality and Myocardial Infarction in Patients At Risk of Myocardial Necrosis Due to ACS Related to the Disease Process or to an Interventional Cardiac Procedure
• SPEED (Strategies for Patency Enhancement in the Emergency Department) - A Phase II, Randomized, Open-label, Angiographic Trial Evaluating the Benefit of ReoPro Bolus Plus 12 Hour Infusion With and Without Thrombolytic Therapy for Acute Myocardial Infarction
• PARAGON-B - A Randomized, Double-blind, Placebo-controlled Study of Lamifiban (Ro 44-9883) in Patients with Unstable Angina, Non-Q Wave Myocardial Infarction
• Dofetilide 128 - A Randomized, Double-blind, Parallel, Placebo-controlled Evaluation of Orally Administered Dofetilide in Patients with Symptomatic Paroxysmal Atrial Fibrillation or Flutter
• Dofetilide 128A Extension - A Long-term Extension Double-blind Converting to Open-label
• SPICE (Study of Patients Intolerant of Converting Enzymes) - A Pilot Phase II Trial and Registry of Patients with Class II-IV Heart Failure and Left Ventricular Dysfunction
• PRAISE 2 (Prospective Randomized Amlodipine Survival Evaluation 2) - A Randomized, Placebo-controlled Trial to Evaluate the Effect of Amlodipine on Mortality in Patients with Severe Non-Ischemic Cardiomyopathy
• Val-HeFT - A Multi-country, Randomized, Double-blind Parallel, Placebo-controlled Trial to Assess the Effect of Valsartan on Morbidity and Mortality, Signs and Symptoms and Quality of Life in Patients with Stable Chronic Congestive Heart Failure (NYHA Class II-IV)
• APLAUD - A 12 Week, Double-blind, Parallel, Placebo-controlled Study to Assess the Safety, Tolerability, Pharmacokinetics and Effect of Platelet Aggregation of a Dose Range of SB 214857 When Added to Aspirin with Myocardial Infarction, Unstable Angina, Transient Ischemic Attack, or Stroke
• ELITE II - A Multi-center, Double-blind, Randomized, Parallel, Captopril-controlled Study to Evaluate the Effects of Losartan on Mortality in Patients with Symptomatic Heart Failure
• SADHART (Sertraline Antidepressant Heart Attack Randomized Trial) - A Randomized, Double-blind, Placebo-controlled Trial of Sertraline (Zoloft) for Major Depression After Acute Coronary Syndromes: Myocardial Infarction or Unstable Angina
• WIZARD - A Randomized, Double-blind, Placebo-controlled Trial of the Effect of Weekly Azithromycin on the Incidence of Coronary Artery Disease in Subjects with Evidence of Exposure to C. Pneumoniae
• CAPRICORN - A Multi-national, Multi-center, Randomized, Double-blind, Parallel Group Study to Determine the Effects of Carvedilol on Mortality in Patients with Left Ventricular Dysfunction, With or Without Clinical Evidence of Heart Failure, Post- myocardial Infarction
• HALT-MI - A Phase 2 Safety and Efficacy Study of Hu23F2G on Patients with Acute Myocardial Infarction with Direct Angioplasty
• ASTRA - A Double-blind, Placebo-controlled, Multi-center Pilot Study to Assess the Safety and ex vivo Platelet Aggregation Response of Intravenous AR-C69931 MX in Patients Undergoing Percutaneous Transluminal Coronary Angioplasty, With or Without Intracoronary Stent Placement
• INTRO-AMI - A Pilot Phase II Safety and Efficacy Evaluation of Eptifbatide (Integrelin) in Patients Receiving Low Dose and Standard Dose Thrombolytic Therapy (Alteplase) for Acute Myocardial Infarction (AMI)
• LIMIT-AMI - A Phase II, Randomized, Double-blind, Placebo-controlled, Multi-center, Angiographic Trial of the Safety and Efficacy of rhuMAb CD18 in Acute Myocardial Infarction
• GUSTO IV-ACS - A Phase III, Randomized, Double-blind, Placebo-controlled Trial Evaluating the Efficacy and Safety of ReoPro, Given as a Bolus Followed by a 24 or 48 Hour Infusion, for the Treatment of Acute Coronary Syndrome Without ST Segment Elevation