Professional Research
Thaddeus R. Tolleson, MD

Research

• Duke Clinical Research Institute
• Clinical Trials in Acute Coronary Syndromes and Percutaneous Interventions: Design, implementation and analysis of multi-center clinical trials in the setting of acute coronary syndromes and coronary interventions. Primary research focuses on clinical outcomes with new antiplatelet agents and antithrombins.
• Developed protocols for phase II (PYRAMID) and phase III (PLATINUM) clinical trials
• Presented study findings at national scientific meetings
• Manuscript preparation for publication in peer-reviewed journals
• Project management including regulatory affairs, budget negotiations, site management and monitoring
• Performed CEC Adjudication/review for multiple phase III clinical trials
• Coordinated clinical hotline for multicenter studies
• University of Texas Medical School - Houston
• Patholophysiology of acute coronary syndromes in canine models. Worked in the laboratory of Richard Smalling, MD, PhD. Developed canine model of acute coronary occlusion to study effects of pharmaceutical agents on infarct size and reperfusion injury.